716 research outputs found

    Comparing National Stereotypes in different cultures: German in Dutch and Russian language teaching at schools and universities

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    Stereotypes, prejudices, hostile images and clichés are different forms of self-images and images of others. This paper establishes stereotypes as a scalable concept to distinguish them from other forms of fixed attributions. It features a comparison of national stereotypes about Germany, the Germans and the German language from a Dutch and Russian perspective and discusses the use of stereotypes in foreign language teaching, which are aimed at culturally reflective learning.Stereotypes, prejudices, hostile images and clichés are different forms of self-images and images of others. This paper establishes stereotypes as a scalable concept to distinguish them from other forms of fixed attributions. It features a comparison of national stereotypes about Germany, the Germans and the German language from a Dutch and Russian perspective and discusses the use of stereotypes in foreign language teaching, which are aimed at culturally reflective learning.Stereotypes, prejudices, hostile images and clichés are different forms of self-images and images of others. This paper establishes stereotypes as a scalable concept to distinguish them from other forms of fixed attributions. It features a comparison of national stereotypes about Germany, the Germans and the German language from a Dutch and Russian perspective and discusses the use of stereotypes in foreign language teaching, which are aimed at culturally reflective learning.Stereotypes, prejudices, hostile images and clichés are different forms of self-images and images of others. This paper establishes stereotypes as a scalable concept to distinguish them from other forms of fixed attributions. It features a comparison of national stereotypes about Germany, the Germans and the German language from a Dutch and Russian perspective and discusses the use of stereotypes in foreign language teaching, which are aimed at culturally reflective learning

    Vier Jahrzehnte erfolgreicher Wissenschaftskooperation der Universitäten Halle und Ulan-Bator

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    The exploration of Asia by scientists from the University of Halle and the Francke Foundations (founded in 1698) has a long tradition, dating back to the 18th century when early researchers reached the northern borders of Mongolia. In 1962 and 1964, the first large biological expeditions were organized by the Academies of Sciences of the GDR and Mongolia, and zoologists from the Universities of Halle, Berlin and Ulan-Bator were part of the expedition teams. These expeditions aimed at the exploration of southern and western Mongolia, and laid the foundation for extremely valuable scientific collections yielding innumerable herbarium specimens and a wide range of zoological material,which are still kept in Germany and especially Mongolia. In 1967, the Universities of Halle and Ulan-Bator signed a contract on cooperation in research programs, education and training of academic youth. Since then, dozens of Mongolian students and scientists were educated and graduated at the University of Halle; today a number of German-speaking staff at the University in Ulan-Bator demonstrates the importance and efficiency of these efforts. The extensive scientific cooperation resulted in some 250 scientific papers, in the joint editing of the journal \u27Exploration of biological resources of Mongolia,\u27 and in the organization of international conferences in 1983 and 1992 in Halle, and 2004 in Ulan-Bator. Up to the present, research is continued and vividly discussed, and much of the scientific output is of fundamental importance for the understanding of Central Asian ecosystems and international nature conservation. A central topic of the hard field work during the last 40 years was research on the ecology of endangered species, and their conservation and management in Central Asian ecosystems and nature reserves. Examples include the Central Asian beaver Castor fiber birulai, the Asiatic wild ass Equus hemionus hemionus, plus various raptor and jerboa species. These studies were augmented by complex programs in biodiversity research. Special focus was also put on the vertical zonation of vegetation, flora and fauna in the high mountains of western and southern Mongolia. Additionally, the effects of the large-scale conversion of near-natural steppes to agricultural land were investigated in western Mongolia with a focus on plant associations and animal communities. During all expeditions the transfer of methods and the qualification of students and young scientists was a central issue. The experimental rearing of economically relevant small mammals such as Alticola species and the endemic steppe vole Microtus brandti formed the basis for a wide range of studies which resulted in several diploma theses and dissertations. In the last years, continued practical training on complex issues of ecosystem ecology and joint supervision of German and Mongolian students in diploma and Ph.D. projects contributed much to the ongoing success of the cooperation, and also to the individual development of the students’ personality. Moreover, a very effective network of the Universities of Marburg and Ulan-Bator lead to the establishment of a research station in the Gurvan Sajkhan National Park, where also botanists from Halle University found ample opportunities for scientific work. After 40 years of close cooperation, the scientific herbarium and the zoological collections of the Martin-Luther-University Halle-Wittenberg are among the largest in Western Europe devoted to Central Asia, and can be regarded as an important world heritage. They form an invaluable source for multilateral and interdisciplinary studies by German scientists and international authorities, and will continue to contribute to scientific progress, to the growing body of knowledge on Central Asian ecosystems and biodiversity, and many other aspects of the physical and cultural geography of Mongolia

    Influence of Invasive Hybrid Cattails on Habitat Use by Common Loons

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    An invasive hybrid cattail species, Typha x glauca (T. x glauca), is rapidly expanding across the United States and Canada. Dense clonal stands of T. x glauca outcompete native wetland plants, reduce open-water habitats, and negatively affect native wetland plant diversity; however, effects of hybrid cattail expansions on native wildlife are still unclear. We used multiple surveys and single-season occupancy models to examine how the relative coverage of T. x glauca affected habitat use by common loons (Gavia immer) at 71 wetland sites in Voyageurs National Park, Minnesota, USA, during summer 2016. Delineated wetland sites (2 ha) were considered potential resource patches for common loons and positioned along a gradient of relative T. x glauca coverage. Detection of common loons was influenced negatively by the time of day surveys were conducted. Occupancy probabilities were greater at sites with deeper water levels, possibly indicating selection for areas with adequate water depths for pursuit-based foraging for fish. Contrary to our hypothesis, common loons appeared insensitive to the relative coverage of T. x glauca at wetland sites. Future research should focus on elucidating potential threshold-effects of T. x glauca expansions on additional loon demographic rates

    Money in monetary policy design: monetary cross-checking in the New-Keynesian model

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    In the New-Keynesian model, optimal interest rate policy under uncertainty is formulated without reference to monetary aggregates as long as certain standard assumptions on the distributions of unobservables are satisfied. The model has been criticized for failing to explain common trends in money growth and inflation, and that therefore money should be used as a cross-check in policy formulation (see Lucas (2007)). We show that the New-Keynesian model can explain such trends if one allows for the possibility of persistent central bank misperceptions. Such misperceptions motivate the search for policies that include additional robustness checks. In earlier work, we proposed an interest rate rule that is near-optimal in normal times but includes a cross-check with monetary information. In case of unusual monetary trends, interest rates are adjusted. In this paper, we show in detail how to derive the appropriate magnitude of the interest rate adjustment following a significant cross-check with monetary information, when the New-Keynesian model is the central bank’s preferred model. The cross-check is shown to be effective in offsetting persistent deviations of inflation due to central bank misperceptions. Keywords: Monetary Policy, New-Keynesian Model, Money, Quantity Theory, European Central Bank, Policy Under Uncertaint

    Sustainable protected areas: Synergies between biodiversity conservation and socioeconomic development

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    Reconciling conservation and socioeconomic development goals is key to sustainability but remains a source of fierce debate. Protected areas (PAs) are believed to play an essential role in achieving these seemingly conflicting goals. Yet, there is limited evidence as to whether PAs are actually achieving the two goals simultaneously.Here, we investigate when and to what extent synergies or trade-offs between biodiversity conservation and local socioeconomic development occur. To explore these relationships, we collected data across a wide range of socioeconomic settings through face-to-face survey with PA managers from 114 African and European PAs using structured questionnaire.We found synergies between biodiversity conservation and socioeconomic development for 62% of the PAs, albeit with significant differences between African (55%) and European PAs (75%). Moreover, the sustainability of PAs in conserving biodiversity was strongly correlated with the empowerment of the PA management and the involvement of local communities in PA planning and decision-making processes.Our results demonstrate that for PAs to promote synergies between biodiversity conservation and local socioeconomic development, and to enhance their long-term sustainability, they should invest in the empowerment of their respective management and involvement of local communities in their planning and management activities.Read the free Plain Language Summary for this article on the Journal blog

    Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures

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    Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated. To explore the mechanism involved, the effect of simvastatin on Toll-like receptor (TLR) signalling in primary human monocytes was investigated. A short pre-treatment with simvastatin dose-dependently inhibited the production of tumor necrosis factor-α (TNF) in response to TLR8 (but not TLRs 2, 4, or 5) activation. Statins are known inhibitors of the cholesterol biosynthetic pathway, but intriguingly TLR8 inhibition could not be reversed by addition of mevalonate or geranylgeranyl pyrophosphate; downstream products of cholesterol biosynthesis. TLR8 signalling was examined in HEK 293 cells stably expressing TLR8, where simvastatin inhibited IKKα/β phosphorylation and subsequent NF-κB activation without affecting the pathway to AP-1. Since simvastatin has been reported to have anti-inflammatory effects in RA patients and TLR8 signalling contributes to TNF production in human RA synovial tissue in culture, simvastatin was tested in these cultures. Simvastatin significantly inhibited the spontaneous release of TNF in this model which was not reversed by mevalonate. Together, these results demonstrate a hitherto unrecognized mechanism of simvastatin inhibition of TLR8 signalling that may in part explain its beneficial anti-inflammatory effects

    Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

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    <p>Abstract</p> <p>Background</p> <p>The World Health Organization endorses the use of artemisinin-based combination therapy for treatment of acute uncomplicated falciparum malaria in the second and third trimesters of pregnancy. However, the effects of pregnancy on the pharmacokinetics of artemisinin derivatives, such as artesunate (AS), are poorly understood. In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin (DHA), were studied in pregnant and non-pregnant women at the Kingasani Maternity Clinic in the DRC.</p> <p>Methods</p> <p>Data were obtained from 26 pregnant women in the second (22 - 26 weeks) or the third (32 - 36 weeks) trimester of pregnancy and from 25 non-pregnant female controls. All subjects received 200 mg AS. Plasma AS and DHA were measured using a validated LC-MS method. Estimates for pharmacokinetic and variability parameters were obtained through nonlinear mixed effects modelling.</p> <p>Results</p> <p>A simultaneous parent-metabolite model was developed consisting of mixed zero-order, lagged first-order absorption of AS, a one-compartment model for AS, and a one-compartment model for DHA. Complete conversion of AS to DHA was assumed. The model displayed satisfactory goodness-of-fit, stability, and predictive ability. Apparent clearance (CL/F) and volume of distribution (V/F) estimates, with 95% bootstrap confidence intervals, were as follows: 195 L (139-285 L) for AS V/F, 895 L/h (788-1045 L/h) for AS CL/F, 91.4 L (78.5-109 L) for DHA V/F, and 64.0 L/h (55.1-75.2 L/h) for DHA CL/F. The effect of pregnancy on DHA CL/F was determined to be significant, with a pregnancy-associated increase in DHA CL/F of 42.3% (19.7 - 72.3%).</p> <p>Conclusions</p> <p>In this analysis, pharmacokinetic modelling suggests that pregnant women have accelerated DHA clearance compared to non-pregnant women receiving orally administered AS. These findings, in conjunction with a previous non-compartmental analysis of the modelled data, provide further evidence that higher AS doses would be required to maintain similar DHA levels in pregnant women as achieved in non-pregnant controls.</p

    Woodlands and steppes: Pleistocene vegetation in Yakutia's most continental part recorded in the Batagay permafrost sequence

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    © 2018 Elsevier Ltd Based on fossil organism remains including plant macrofossils, charcoal, pollen, and invertebrates preserved in syngenetic deposits of the Batagay permafrost sequence in the Siberian Yana Highlands, we reconstructed the environmental history during marine isotope stages (MIS) 6 to 2. Two fossil assemblages, exceptionally rich in plant remains, allowed for a detailed description of the palaeo-vegetation during two climate extremes of the Late Pleistocene, the onset of the last glacial maximum (LGM) and the last interglacial. In addition, altogether 41 assemblages were used to outline the vegetation history since the penultimate cold stage of MIS 6. Accordingly, meadow steppes analogue to modern communities of the phytosociological order Festucetalia lenensis formed the primary vegetation during the Saalian and Weichselian cold stages. Cold-resistant tundra-steppe communities (Carici rupestris-Kobresietea bellardii) as they occur above the treeline today were, in contrast to more northern locations, mostly lacking. During the last interglacial, open coniferous woodland similar to modern larch taiga was the primary vegetation at the site. Abundant charcoal indicates wildfire events during the last interglacial. Zoogenic disturbances of the local vegetation were indicated by the presence of ruderal plants, especially by abundant Urtica dioica, suggesting that the area was an interglacial refugium for large herbivores. Meadow steppes, which formed the primary vegetation during cold stages and provided potentially suitable pastures for herbivores, were a significant constituent of the plant cover in the Yana Highlands also under the full warm stage conditions of the last interglacial. Consequently, meadow steppes occurred in the Yana Highlands during the entire investigated timespan from MIS 6 to MIS 2 documenting a remarkable environmental stability. Thus, the proportion of meadow steppe vegetation merely shifted in response to the respectively prevailing climatic conditions. Their persistence indicates low precipitation and a relatively warm growing season throughout and beyond the late Pleistocene. The studied fossil record also proves that modern steppe occurrences in the Yana Highlands did not establish as late as in the Holocene but instead are relicts of a formerly continuous steppe belt extending from Central Siberia to Northeast Yakutia during the Pleistocene. The persistence of plants and invertebrates characteristic of meadow steppe vegetation in interior Yakutia throughout the late Quaternary indicates climatic continuity and documents the suitability of this region as a refugium also for other organisms of the Pleistocene mammoth steppe including the iconic large herbivores
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